Metamenu

  • Centre for Microbiology and Environmental Systems Science

  • CUBE - Computational Systems Biology

  • DOME - Microbial Ecology

  • EDGE - Environmental Geosciences

  • TER - Terrestrial Ecosystem Research

News

Latest publications

Targeting Gut Bacteria Using Inulin-Conjugated Mesoporous Silica Nanoparticles

To facilitate the creation of novel nanocarrier systems targeting the intestinal microbiome, inulin-conjugated mesoporous silica nanoparticles (MSNs) are described herein for the first time. Surface functionalization is achieved on either hydrophilic or hydrophobic mesoporous nanoparticles using different conjugation methods. The targeting performance of the resulting materials is assessed and compared upon incubation with human stool. It appears that amide formation is the most favorable coupling method on hydrophilic MSNs to achieve the desired bioconjugate. Remarkably, high affinity of gut bacteria to the conjugated particles can be obtained, paving the way to novel targeted drug delivery systems.

von Baeckmann C, Riva A, Guggenberger P, Kählig H, Han SW, Inan D, Del Favero G, Berry D, Kleitz F
2022 - Adv Mater Interfaces, 9: 202102558

Elucidating the role of the gut microbiota in the physiological effects of dietary fiber

Dietary fiber is an integral part of a healthy diet, but questions remain about the mechanisms that underlie effects and the causal contributions of the gut microbiota. Here, we performed a 6-week exploratory trial in adults with excess weight (BMI: 25–35 kg/m2) to compare the effects of a high-dose (females: 25 g/day; males: 35 g/day) supplement of fermentable corn bran arabinoxylan (AX; n = 15) with that of microbiota-non-accessible microcrystalline cellulose (MCC; n = 16). Obesity-related surrogate endpoints and biomarkers of host-microbiome interactions implicated in the pathophysiology of obesity (trimethylamine N-oxide, gut hormones, cytokines, and measures of intestinal barrier integrity) were assessed. We then determined whether clinical outcomes could be predicted by fecal microbiota features or mechanistic biomarkers.

Deehan EC, Zhang Z, Riva A, Armet AM, Perez-Muñoz ME, Nguyen NK, Krysa JA, Seethaler, B Zhao Y-Y, Cole J, Li F, Hausmann B, Spittler A, Nazare J-A, Delzenne NM, Curtis JM, Wismer WV, Proctor SD, Bakal JA, Bischoff SC, Knights D, Field CJ, Berry D, Prado CM, Walter J
2022 - Microbiome, in press

Targeting Gut Bacteria using Inulin-Conjugated Mesoporous Silica Nanoparticles

To facilitate the creation of novel nanocarrier systems targeting the intestinal microbiome, inulin-conjugated mesoporous silica nanoparticles (MSNs) are described herein for the first time. Surface functionalization is achieved on either hydrophilic or hydrophobic mesoporous nanoparticles using different conjugation methods. The targeting performance of the resulting materials is assessed and compared upon incubation with human stool. It appears that amide formation is the most favorable coupling method on hydrophilic MSNs to achieve the desired bioconjugate. Remarkably, high affinity of gut bacteria to the conjugated particles can be obtained, paving the way to novel targeted drug delivery systems.

von Baeckmann C, Riva A, Guggenberger P, Kählig H, Han SW, Inan D, Del Favero G, Berry D, Kleitz F
2022 - Advanced Materials Interfaces, in press

Lecture series

EDGE Lecture: Nanoparticles for Efficient Delivery of Agrochemicals in Crop Plants: Challenges and Opportunities

Prof. Subhasis Ghoshal
McGill University, CAN
24.05.2022
16:00 h
Seminar room "M. Neumayr" (2A502, UZA 2)

EDGE Lecture: Tuning agrochemical chemistry at the nanoscale to enhance stress tolerance, crop nutrition and yield

Dr. Jason C. White
The Connecticut Agricultural Experiment Station, USA
02.06.2022
17:00 h
Online

EDGE Lecture: Fate of synthetic biodegradable polymers in soils

Prof. Michael Sander
ETH Zürich, Switzerland
09.06.2022
17:00 h
tba